Glucose accumulation by rings of small intestine from normal and schistosome-infected mice.
نویسندگان
چکیده
serosal permeability to sugars (Holman & Naftalin, 1975). With a preparation of the mucosa of rabbit ileum and the sugar galactose, these authors were able to show that, although theophylline and dibutyryl cyclic AMP had no effect on the entry or exit permeabilities to galactose at the mucosal pole of the epithelium, both the serosal entry and the exit permeability were decreased to 30% of control values. When the present results are expressed in terms of sugar concentration rather than absolute amounts (Fig. 2), they show that the glucose concentration in the serosal exudate continues to rise throughout the incubation period in the presence of theophylline, whereas in control preparations it reaches a steady state. This is significant in that Holman & Naftalin (1975) similarly reported that theophylline increased the steady-state concentration of galactose in the tissue water of the rabbit mucosa. We think the most likely explanation of our results is in terms of the intercellular spaces bordering the lateral and basal aspects of the epithelial cells. These spaces are usually distended when fluid is being absorbed by the epithelium, but under conditions of diminished salt absorption brought about by a rise in mucosal cyclic AMP concentration, the spaces are extremely small, and the membranes bordering them in tight apposition (Di Bona et ul., 1974; Holman & Naftalin, 1975). Under these conditions there is likely to be less wash-out of the intercellular spaces, leading to the build-up of the high solute concentration reflected in the serosal exudate.
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عنوان ژورنال:
- Biochemical Society transactions
دوره 4 2 شماره
صفحات -
تاریخ انتشار 1976